New tricks of well-known aminoazoles in isocyanide-based multicomponent reactions and antibacterial activity of the compounds synthesized

نویسندگان

  • Maryna V Murlykina
  • Maryna N Kornet
  • Sergey M Desenko
  • Svetlana V Shishkina
  • Oleg V Shishkin
  • Aleksander A Brazhko
  • Vladimir I Musatov
  • Erik V Van der Eycken
  • Valentin A Chebanov
چکیده

The well-known aminoazoles, 3-amino-5-methylisoxazole and 5-amino-N-aryl-1H-pyrazole-4-carboxamides, were studied as an amine component in Ugi and Groebke-Blackburn-Bienaymé multicomponent reactions. The first example of an application of aminoazoles in an Ugi four-component reaction was discovered and novel features of a Groebke-Blackburn-Bienaymé cyclocondensation are established and discussed. The heterocycles obtained were evaluated for their antibacterial activity and several of them demonstrated a weak antimicrobial effect, but for most of the compounds a 30-50% increase in biomass of Gram-positive strains (mainly B. subtilis) compared to control was observed.

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عنوان ژورنال:

دوره 13  شماره 

صفحات  -

تاریخ انتشار 2017